November 29, 2011: Simon Karpatkin Memorial Lecture: Thiol Isomerases As Novel Antithrombotic Targets
Bruce Furie, MD, Harvard Medical School, Beth Israel Deaconess Medical Center
New York University Langone Medical Center, New York, NY
Table of Contents
Thiol Isomerases as Novel Antithrombotic Targets
0:03:46
The Karpatkin Legacy:
0:08:34
Trousseau's Syndrome
0:09:50
Linkage Analysis: Cancer Database-Anticoagulation Database
0:10:46
Molecular and Cellular Basis of Thrombosis in Cancer?
0:11:36
Role of P-Selectin in Thrombus Formation
0:11:42
Arterial Thrombosis Formation in Genetically Altered Mice
0:13:35
Platelet and fibrin deposition in wt and genetically altered mice
0:14:38
Infusion of PSGL-1-Bearing Microparticles Prior to Thrombus Formation
0:18:18
Might blood microparticles containing tissue factor play a pathologic role in the link between cancer and thrombosis?
0:19:27
Cancer and Microparticles
0:19:52
Enrollment criteria:
0:21:01
Tissue factor microparticles are associated with acute VTE in cancer patients
0:21:51
TF Microparticles before and after pancreatectomy in patients with pancreatic cancer
0:23:33
Conclusions
0:25:24
Design of prospective trial to evaluate TF-bearing microparticles as a biomarker for patients who will benefit from thromboprophylaxis
0:25:49
MicroTEC Preliminary Results
0:27:04
Cancer-Associated Thrombosis
0:27:48
Clinical Manifestations
0:28:20
International Consensus Statement on Classification Criteria for Anti Phospholipid Syndrome (APS)
0:28:57
Diagnostic Criteria
0:30:13
Clinical Features of Patients with APS
0:30:25
Anti-B2GP1 lgG isolation
0:31:59
Infusion of anti-beta-2 glycoprotein 1 antibodies increased thrombus size in a dose-dependent manner
0:32:18
Beta2GPI antibody is directed against platelets
0:33:02
Treatment of Antiphospholipid Syndrome
0:33:27
PDI and other oxido reductases are found outside of the ER
0:37:06
In Vivo Blood Coagulation
0:37:50
Thiol Isomerases
0:38:34
Expression of Thiol Isomerase Antigens During Thrombus Formation
0:39:37
Expression and Platelet Accumulation
0:40:21
Thiol Isomerases are Required for Thrombus Formation
0:41:11
[Extracellular] PDI as a target for anti-thrombotic therapy?
0:42:39
Identities of Hits
0:43:42
Rutin (Quercetin rutinoside)
0:44:44
Rutin Inhibits Thrombus Formation
0:45:03
Mouse Model of Antiphospholipid Syndrome
0:45:53
Conclusions
0:46:06
Collaborators
0:47:40
No Description
 
  • Comments
  • Description
   
Sign up to Add Comment!
 
Characters Left :
  
    Brief Description
 
Dr. Furie presents on platelet biology and thrombosis.
 
    Full Description
 
 
    Citation
 
 
    Abstract
 
 
    Introduction
 
 
    Results
    Discussions
 
 
    Material Methods
 
 
    References
 
 
 
 
Stats
 
Publish date Views Ref#
Dec 07, 2011 801 VA:12:05:6776:2011
 
Rating
   
 
Your rating: None
 
Embed Code
 
Files
 
 
 

Contact Us | Investors | About VeoMed | News | Help

Copyright ® VeoMed.com 2006-2007 All Rights Reserved    Privacy Policy | Terms of Use

Quick Links
Open Access
My Dashboard
Login
Signup