Mechanisms of Action of General Anesthetics
James P. Dilger
Dept of Anesthesiology, Health Sciences Center, SUNY, Stony Brook, NY 11794-8480
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    Brief Description
 
Dr. James Dilger discusses the mechanism of action of general anesthetics.
 
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    Material Methods
 
 
    References
 
Alkire MT, McReynolds JR, Hahn EL, Trivedi AN. Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat. Anesthesiology 107: 264-672, 2007

Antognini JF, Schwartz K. Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology 79: 1244-1249 , 1993

Dilger JP, Vidal AM, Mody HI, Liu Y Evidence for direct actions of general anesthetics on an ion channel protein - a new look at a unified mechanism of action. Anesthesiology 81: 431-442, 1994

Eger EI, Koblin DD, Harris RA, Kendig JJ, Pohorille A, Halsey MJ, Trudell JR Hypothesis - inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites. Anesthesia & Analgesia. 84:915-918, 1997

Franks NP, Lieb WR Molecular and cellular mechanisms of general anaesthesia. Nature 367: 607-614 , 1994

Franks NP, Lieb WR Do general anaesthetics act by competitive binding to specific receptors? Nature 310: 599, 1984

Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, Rudolph U. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABAA receptor b3 subunit. FASEB J 17, 250, 2003

Koblin DD, Chortkoff BS, Laster MJ, Eger EI, Halsey MJ, Ionescu P Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis. Anesthesia and Analgesia 79: 1043-1048, 1994

Krasowski MD, Koltchine VV, Rick CE, Ye Q, Finn SE, Harrison NL. Propofol and other intravenous anesthetics have sites of action on the g-aminobutyric acid type A receptor distinct from that for isoflurane. Molecular Pharmacology 53: 530-538,1998

Mascia MP, Trudell JR, Harris RA. Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci U S A. 97:9305-10, 2000

Rampil IJ, Mason P, Singh H Anesthetic potency (MAC) is independent of forebrain structures in the rat. Anesthesiology 78: 707-712 , 1993

Sebel PS, et al. The incidence of awareness during anesthesia: A multicenter United States study. Anesth Analg 99:833-9, 2004

Solt K, Forman SA. Correlating the clinical actions and molecular mechanisms of general anesthetics. Curr Opin Anaesth 20:300-6, 2007

Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Rampil IJ, Trudell J, Vissel B, Eger EI. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth Analg. 97:718-40, 2003

 
 
 
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Sep 24, 2010 1348 VA:09:24:5063:2010
 
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