May 22, 2012; Treatment of Type 1 Diabetes from Biologics to Bionics: Metabolic Memory and Its Implications

May 22, 2012; Treatment of Type 1 Diabetes from Biologics to Bionics: Metabolic Memory and Its Implications
David M. Nathan, MD, NYU School of Medicine
New York University Langone Medical Center, New York, NY

Table of Contents

A History of T1DM Therapy

0:03:06

Pre-Insulin Era

0:05:55

Birth of the Insulin Era

0:06:57

The Shot Heard Around the World

0:08:08

Early Results of the Insulin Era: 1930-1960

0:10:47

Exploring the Glucose Hypothesis

0:11:50

Intensive Therapy Goals

0:13:01

Intensive Therapy Methods

0:14:11

Intensive Therapy Regimens

0:15:05

Completeness of Follow-up and Adherence to Study Protocol

0:15:40

DCCT

0:17:00

Effect of Intensive Therapy

0:18:10

DCCT Treatment Group Effects PErcent Explained By DCCT HbA1c

0:19:04

Association of HbA1c with Risk Retinopathy

0:20:06

Risk of Severe Hypoglycemia during DCCT

0:21:35

Epidemiology of Diabetes Interventions and Complications

Cardiovascular Events

0:29:43

Potential Explanations for Metabolic Memory

0:31:38

Glycation

0:33:16

Evidence that Glycation Mediates Long-term Complications

0:35:55

Post-DCCT Intensive Therapy Era

Continuous Glucose Monitoring System

0:46:43

Temporal Changes in Glycemic Control 1985-2010

0:47:54

Prevalence (%) of Severe Complications after 30 years

0:50:07

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Dr. Nathan presents on Type 1 diabetes treatment.

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