May 1, 2012; Allergy, Asthma and Microbes: Investigating the Hygiene Hypothesis
Homer Boushey, MD, University of California San Francisco
New York University Langone Medical Center, New York, NY
Table of Contents
Allergy, Asthma, and Microbes: Investigating the Hygiene Hypothesis
0:00:22
Disclosures
0:05:16
Outline
0:05:30
The Microbiome
0:05:57
Dimensions of the Microbial World
0:06:57
Gene for 16S rRNA
0:08:11
16S rRNA-based tools characterize microbial ecology in human niches
0:11:40
Childhood Asthma after Bacterial Colonization of the Airway in Neonates
0:12:41
Relating Disease Features to Microbial Community Composition
0:14:08
MIA Protocol
0:16:36
MIA Ancillary Study, Characterizing Bronchial Microbiota
0:19:25
Study Enrollment
0:19:52
Bacterial Bioburden Greater in Asthmatics
0:20:12
Clinical Variables: Relationships to 16S rRNA Bacterial Bioburden
0:21:06
BActerial Groups More Common Among Asthmatics
0:22:06
Summary of Study Findings
0:23:20
Disordered Microbial Communities in Asthmatic Airways
0:24:28
Next Study of Airway Microbiome in Asthma
0:24:55
Final Diagnosis
0:24:55
Study Design
0:25:22
Analysis Goals
0:25:42
Farm Animal Exposure and Allergy Risk
0:27:36
Detroit Childhood Allergy-Asthma Study
0:28:57
First Year Pet Exposure and Allergic Sensitivity
0:29:31
Unpasteurized Milk
0:31:18
Drinking Water, Microbes, and Atopy
0:32:26
Common Features of Most Published Studies
0:33:53
Microbiota Hypothesis
0:34:27
Acquisition of Bacteria from House Dust
0:35:14
Soil and House Dust Ingestion by Children
0:36:08
Bacterial Ingestion from House Dust
0:36:41
Microbial Environment and Development of Asthma
0:37:08
Th-17 Cell Dependence on Intestinal Bacteria in Mice
0:39:03
Feeding GF Mice Segmented Filamentous Bacteria Induces Th-17 Cell Expansion
0:40:24
Gut Microbial Community Composition and Immune Function Relevant to Allergy & Asthma
0:41:04
First Year Pet Exposure and Allergic Sensitivity
0:43:05
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Dr. Boushey discusses the hygiene hypothesis and asthma.
 
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May 02, 2012 562 VA:05:01:7340:2012
 
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