April 19, 2012: Evolving Concepts in the Pathophysiology and Treatment of Obsessive Compulsive Disorder

April 19, 2012: Evolving Concepts in the Pathophysiology and Treatment of Obsessive Compulsive Disorder
Norman Sussman, MPA, MD, DFAPA Professor of Psychiatry, Associate Dean for Postgraduate Programs New York University School of Medicine
New York University Langone Medical Center, New York, NY

Table of Contents

Intro

0:00:00

"Obsessive Compulsive Reaction"

0:04:41

Phenotypic Correlations bt/wn the 5 Obsessive-Compulsive Symptom Dimensions

0:06:15

OCD Prevalence

0:07:38

OCD: Under-Diagnosis/Misdiagnosis

0:11:01

Causes of Diagnostic Errors

0:12:12

When is it a disorder?

0:13:18

Explaining Harm Avoidance

0:13:54

Core OCD Phenomenology

0:16:40

Clues to Diagnosis of OCD in the Clinical Setting

0:18:16

Procrastination as a Symptom of OCD

Genetic Contribution to OCD

0:25:18

Endophenotypes

0:26:06

Orbitofrontal Dysfunction in Patients with OCD

0:28:23

SLC6A4 Gene Polymorphisms

0:29:05

Pathological Grooming Behaviors

0:30:16

Mouse Trichotillomania?

0:31:45

Altered cortico-striatal synaptic transmission in mice

0:32:21

Fluoxeine treatment

0:33:03

SLC1A1: Clinical Implications

0:34:44

Hoxb8 Gene, Microglial Immune Function and Pathological Grooming

0:35:32

CNS Autoimmunity, Inflammation and Pregnancy as Etiological Factors in OCD

0:37:25

Association bt/wn Inflammation and OCD

0:38:06

Celecoxib as an Adjunct in the Treatment of OCD

0:38:30

PANDAs: Diagnostic Criteria

0:39:42

Proving Autoimmune Mechanisms in PANDAs

0:40:47

Mouse Model of PANDAs

0:40:59

Anti Basal Ganglia Antibodies (AGBA) in OCD

0:41:29

Body Dysmorphic Disorder (BDD)

0:42:10

Psychopharmacology of OCD

0:43:22

Glutamatergic Transmission Inhibitors

0:43:40

NAC in Trichotillomania

0:44:21

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Dr. Norman Sussman speaks about evolving concepts in the pathophysiology and treatment of obsessive compulsive disorder.

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