April 17, 2012; Herbert Chasis Lecture: Pathogenesis of Preeclampsia

April 17, 2012; Herbert Chasis Lecture: Pathogenesis of Preeclampsia
S. Ananth Karumanchi, MD, Harvard Medical School
New York University Langone Medical Center, New York, NY

Table of Contents

Preeclampsia/Eclampsia

0:05:32

Preeclampsia

0:07:00

Risk Factors for Preeclampsia

0:07:50

Randomized Trials

0:08:51

Parikh S & Karumanchi SA, Nature Medicine, 2008

0:11:03

Structure of soluble fms-like tyrosine kinase 1 (sFlt1 or sVEGFR1)

0:15:05

Angiogenic Imbalance in Preeclampsia

0:15:59

Soluble Fms-like Tyrosine Kinase 1 (sFlt1)

0:16:42

Human Analog of sFlt1 Overexpression

0:18:36

Role of VEGF in glomerular endothelium

0:19:54

Gestational pattern of sFlt1 throughtout pregnancy

0:21:39

Prediction of Preeclampsia

0:22:52

Angiogenic Factors and Trisomy 13

0:25:53

Diagnostic and Therapeutic Implications

0:26:56

Neonatal Complications by Gestational Age

0:27:27

Diagnostic Study Design

0:28:39

Aid in diagnosis of preterm preeclampsia

0:29:23

ROC analysis for sFlt1/PIGF ratio

0:30:24

Preeclampsia and Adverse Outcomes

0:31:20

Strategies for Therapy

0:32:42

Reversal of PE in the uterine ischemia model

0:35:12

Other Strategies

0:35:45

Dextran Sulfate Apheresis for Homozygous Hyperlipidemia

0:36:57

Study with Liposorber Columns Using Human Blood

0:38:36

Dextran Sulfate Apheresis for Preeclampsia

0:40:27

Liver Histology

0:42:56

Effects of VEGF and TGFB neutralization on brian permeability

0:43:18

Angiogenic Imbalance in Preeclampsia

0:44:47

Conclusions

0:45:09

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Dr. Karumanchi presents on preeclampsia at the Herbert Chasis lecture.

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