Assembly: Making New Virus Particles | VEOMED

Assembly: Making New Virus Particles
Vincent Racaniello
Columbia University, New York, NY

Table of Contents

All virions complete a common set of assembly reactions

A tale of two picornaviruses

All infectious virions must be METASTABLE structures

Production of virus particles depends on host cell machinery

Concentrating components for assembly: Nothing happens fast in dilute solutions

Viral proteins achieve high concentrations by several methods

Getting things to the right place

Viral proteins have ‘addresses’ built into their structure

Localization of viral proteins to the nucleus

Movement of VSV nucleocapsids in cytoplasm requires microtubules

Three strategies for making sub--assemblies

Assembly intermediates and the assembly--line concept

Self--assembly versus assisted assembly reactions

Genome Packaging

Packaging signals- DNA genomes

Packaging of segmented genomes

Selective packaging

Acquistion of an envelope

Four budding strategies

Involvement of the ESCRT machinery in three topologically equivalent types of membrane abscission

The majority of viruses leave an infected cell by one of two general mechanisms

Why do infected cells lyse?

No Description

Comments
Description

Sign up to Add Comment!

Characters Left :

Brief Description

This lectures is on the assembly of new virus particles by Vincent Racaniello,

Full Description

Citation

Abstract

Introduction

Results

Discussions

Material Methods

References

Stats

Publish date	Views	Ref#
Sep 03, 2010	1286	VA:04:16:4209:2010

Rating


	Average: Your rating: None

Embed Code

 <div id="videoiframe" name="videoiframe"><script src="http://player.ooyala.com/player.js?width=650&height=425&wmode=opaque&embedCode=0yeHYxMjrvG1IxYN3kQnkYG2EMl-S7Fx&videoPcode=&callback=receiveOoyalaEvent&playerId=player&hide=sharing,info,embed&autoplay=0"></script><input type="hidden" id="cc_lang" value=""/></div>

Files

Contact Us | Investors | About VeoMed | News | Help

Copyright ® VeoMed.com 2006-2007 All Rights Reserved Privacy Policy | Terms of Use

Quick Links
Open Access My Dashboard	Login Signup