ShK-peptide treatment of Lewis rats with adoptive EAE (Beeton et al., Proc. Natl. Acad. Sci. USA. 98, 13942, 2001)
Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E.
(1) Laboratoire d'Immunologie, Faculté de Médecine, 13385 Marseille, France; (2) Department of Physiology and Biophysics, University of California, Irvine, CA 92697; (3) Bachem Bioscience, King of Prussia, PA 19406
Adoptive transfer of myelin basic protein-specific T cells (PAS cells) into healthy Lewis rats induces experimental autoimmune encephalomyelitis, a disease resembling multiple sclerosis. If the rats are administered the potent Kv1.3 blocker, ShK peptide, by intraperitoneal injection, the disease is prevented. In contrast, rats administered saline by intraperitoneal injection get the multiple sclerosis-like disease.
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Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13942-7.
Beeton C, Barbaria J, Giraud P, Devaux J, Benoliel AM, Gola M, Sabatier JM, Bernard D, Crest M, Béraud E. Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation. J Immunol. 2001 Jan 15;166(2):936-44.
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