Saline treated Lewis rats with adoptive EAE (Beeton et al., Proc. Natl. Acad. Sci. USA. 98, 13942, 2001)
Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E.
(1) Laboratoire d'Immunologie, Faculté de Médecine, 13385 Marseille, France, (2) Department of Physiology and Biophysics, University of California, Irvine, CA 92697; Bachem Bioscience, King of Prussia, PA 19406
Adoptive transfer of myelin basic protein-specific T cells (PAS T cell line) into healthy rats induces experimental autoimune encephalomyelitis (EAE), a disease resembling human multiple sclerosis. Treatment with the potent inhibitor of voltage-gated Kv1.3 potassium channels in the disease-inducing T cells, both prevents and treats the disease.
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Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001, 98:13942-7.
Beeton C, Barbaria J, Giraud P, Devaux J, Benoliel AM, Gola M, Sabatier JM, Bernard D, Crest M, Béraud E. Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation. J Immunol. 2001, 166:936-44.
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