SK3-1B-GFP transgenic mouse showing ataxia while walking along the edge a container (Shakkottai V et al, J. Clinical In

Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG.
(1) Department of Physiology and Biophysics, and Department of Neurobiology and Behavior, and Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, California, USA; (2) University of Innsbruck, Department of Biochemical Pharmacology, Innsbruck, Austria; (3) Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, California, USA
 
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Genetic silencing of small-conductance calcium-activated potassium channels in deep cerebellar neurons of transgenic mice produced cerebellar ataxia.
 
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Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG. Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. J Clin Invest. 2004, 113:582-90.

Orr HT. Into the depths of ataxia. J Clin Invest. 2004, 113:505-7.

 
 
 
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Jan 29, 2009 723 VA:02:17:35:2009
 
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